Endocrine Abstracts

Background: In acromegaly, carbohydrate metabolism disorders (CMD) are frequently observed. The effect of therapy of acromegaly on pathogenesis of CMD is not clear.Aim: To assess the effect of somatostatin analogues (SSA) on pathogenesis of carbohydrate metabolism disturbance in acromegaly.Patients and methods: 103 acromegaly patients were examined (31 men, 72 women; age 54 (46–61) years; 60 had newly diagnosed acromegaly (NA)...

Background: In acromegaly, carbohydrate metabolism disorders (CMD) are frequently observed. We aimed to assess the differences in insulin secretion and sensitivity depending on stage of the disease and type of treatment.Design: Sixty-four patients with acromegaly (46 women; age 53 (interquartile range, IQR 47–59) years), of whom 29 were newly-diagnosed (NA group), 20 treated with somatostatin analogues (SSA group) and 15 after transsphenoïdal s...

TSH producing pituitary adenomas are a rare cause of thyrotoxicosis. These tumors account for only 1–2% of the pituitary adenomas. Co-secretion occurs in 30% of thyrotropinomas and requires careful investigation and subsequent follow up.A 43-year-old male presented with hand tremor and tachycardia. He was found to have elevated TSH, free T4 (FT4) and free T3 (FT3), but did not get treatment for years. In 2019 he developed atrial fibrillation. TSH wa...

Insulinomas are predominantly benign pancreatic neuroendocrine tumors presenting with hyperinsulinemic hypoglycemia. Surgical resection is currently the standard treatment for pancreatic insulinoma, but other treatment options, such as oral medication with diazoxide may be necessary for symptomatic patients who are not candidates for surgical resolution or for those who need bridging therapy till the surgical intervention. We present the case of a 54-year-old man who was admit...